Purpose: To compare left-ventricular global radial strain (GRS) and global circumferential strain (GCS) values measured using automated DeepStrain analysis of short-axis cine images to those calculated using manual commercially available FT analysis.
Study Type: Retrospective, single-center.
Population: A total of 30 healthy subjects and 120 patients with cardiac disease for DeepStrain development. For evaluation, 47 healthy subjects (36 male, 53 5 years) and 533 patients who had undergone a clinical cardiac MRI (373 male, 59 ±14 years).
Field Strength/Sequence: bSSFP sequence at 1.5 T (Phillips) and 3 T (Siemens).
Assessment: Automated DeepStrain measurements of GRS and GCS were compared to commercially available FT (Circle, cvi42) measures obtained by readers with 1 year and 3 years of experience. Comparisons were performed overall and stratified by scanner manufacturer.
Statistical Tests: Paired t-test, linear regression slope, Pearson correlation coefficient (r).
Results: Overall, FT and DeepStrain measurements of GCS were not significantly different (P=0.207), but measures of GRS were significantly different. Measurements of GRS from Philips (slope =1.06 [1.03 1.08], r=0.85) and Siemens (slope =1.04 [0.99 1.09], r=0.83) data showed a very strong correlation and agreement between techniques. Measurements of GCS from Philips (slope =0.98 [0.98 1.01], r=0.91) and Siemens (slope =1.0 [0.96 1.03], r=0.88) data similarly showed a very strong correlation. The average analysis time per subject was 4.1 1.2 minutes for FT and 34.7 3.3 seconds for DeepStrain, representing a 7-fold reduction in analysis time.
Data Conclusion: This study demonstrated high correlation of myocardial GCS and GRS measurements between freely available fully automated DeepStrain and commercially available manual FT software, with substantial time-saving in the analysis.